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Safemedtrip - pediatric bone marrow transplant

Pediatric Bone Marrow Transplant, Stem Cell Transplant for Treatment of Pediatric Cancer, Blood Disorders, Sickle Cell Disease at World Class Hospital in India.

Treatments of Sickle Cell Disease and Sickle Cell Anemia

The Stem Cell Transplant Center at hospitals in India perform autologous and allogeneic stem cell transplants (also called bone marrow transplants) to treat and support the treatment of pediatric cancers, blood disorders, and other conditions.

Pediatric Bone Marrow TransplantWe are one of the largest and most experienced pediatric stem cell transplant programs in the world, performing more than 100 transplants per year. Our team includes doctors and scientists who are leaders in pediatric stem cell transplantation, as well as nationally known pediatric subspecialists.

Our state-of-the-art stem cell transplant facility is designed specifically for children and teens undergoing stem cell transplant – minimizing their exposure to harmful toxins and germs without preventing their freedom to leave their room or interact with family and friends.

We understand the difficult choices that parent’s have to make when considering a blood and marrow transplant. Let us support you. We are here to help.

Bone marrow transplantation (BMT) is a highly advanced medical procedure being used to treat diseases once thought to be incurable. Since its first successful use in 1968, BMTs have been used to treat patients diagnosed with leukaemia, aplastic anaemia, lymphomas such as Hodgkin’s disease, multiple myeloma, immune deficiency disorders and some solid tumours such as breast and ovarian cancer.Request a Call BackRequest a Call Back

Bone Marrow Transplant – When is it Required?

Pediatric Bone Marrow TransplantSometimes the marrow is diseased in certain cancerous and non-cancerous diseases like leukaemia, lymphoma, multiple myeloma, sickle celled anaemia, thalassemia, aplastic anaemia, congenital neutropenia etc. In some other cases the bone marrow is destroyed by heavy doses of chemotherapy for cancers elsewhere in the body. In these cases replacement by a healthy bone marrow is required for the survival of the patient.

This replacement of the diseased or destroyed bone marrow by a healthy marrow is known as bone marrow transplant (BMT). In all these cases there is malfunctioning of the bone marrow which results in reduced / defective blood cell productionIn a bone marrow transplant, healthy marrow is infused into the patient’s blood-stream. In a successful transplant, the new bone marrow migrates to the cavities of the large bones, engrafts and begins producing normal blood cells. Post a QueryPost a Query

Treatments of Sickle Cell Disease and Sickle Cell Anemia

Sickle cell anemia is an inherited blood disorder that causes blood cells to become hard, sticky and shaped like a sickle or “C.” As a result, while traveling through the blood vessels, cells may become stuck and block the flow of blood throughout the body. This may cause a variety of symptoms and medical problems, including bacterial infections, pain, tissue damage, stroke and anemia. Blocked blood flow also can cause damage to the spleen, kidneys and liver.

  • Treatments of Sickle Cell Disease and Sickle Cell Anemia Hydroxyurea (Droxia, Hydrea): This prescription drug, originally used to treat cancer, may be helpful for children and adults with sickle cell disease. When taken daily, it reduces the frequency of painful crises and acute chest syndrome and also reduces the need for blood transfusions. It works by causing an increase in fetal hemoglobin (a type of hemoglobin found in newborn babies) that prevents the formation of sickle cells. This is a preventative medicine only. It does not relieve pain once a patient has already developed a pain crisis.
  • Blood Transfusions: Simple blood transfusions can also be given at a regular schedule (every 4-6 weeks) to prevent sickle cell problems. In some instances, patients are placed on a special machine so they can receive exchange transfusions where 6 to 10 units or a total of 1500 cc are replaced with normal blood cells. The most common reason that children receive scheduled transfusions is for the prevention of stroke. Blood transfusions are very effective at preventing stroke as well as preventing pain crises, acute chest syndrome, enlarged spleen (splenic sequestration) and allowing leg ulcers to heal.
  • Bone Marrow Transplant: Because red blood cells are made in the bone marrow, a bone marrow transplant is a potential cure for sickle cell disease. In a bone marrow transplant, a patient is given high dose chemotherapy and usually radiation to the entire body to wipe out the bone marrow. Then, bone marrow from a donor (usually a sibling) is given through an IV to the patient. The donor bone marrow cells repopulate the patient’s bone marrow and start to make red blood cells, which are normal red blood cells that do not sickle.One problem with transplant is that it is often difficult to find a bone marrow donor who is a match. Also, because of the high dose chemotherapy and radiation, patients can experience many side effects and there is a 5-10% risk of death. Recently, doctors have been performing bone marrow transplants using less intense chemotherapy and radiation to try and reduce the side effects and the risk of death.Request a Call BackRequest a Call Back

Childhood Conditions Treated With Bone Marrow Stem Cell Transplant

Stem Cell Transplant (also called Bone Marrow Transplant) is Used to Treat Many Conditions Affecting Children and Teens, Including:

  • Cancers and Blood Disorders
  • Acute lymphoblastic leukemia (ALL) – including relapsed ALL
  • Acute myelogenous leukemia (AML)
  • Aplastic anemia
  • Brain tumors
  • Chronic myelogenous leukemia
  • Dyskeratosis Congenita
  • Fanconi anemia
  • Hodgkins lymphoma
  • Myelodysplastic syndrome
  • Non-Hodgkins lymphoma
  • Sickle cell disease
  • Solid tumors such as neuroblastoma and Wilms’ tumor
  • ThalassemiaRefer a PatientRefer a Patient

Bone Marrow Transplant Procedure

Bone Marrow Transplant Procedure

Step 1 Extraction / Harvesting of bone marrow cells from the donor by making few punctures under General Anaesthesia. High dose of chemotherapy or radiotherapy is given to destroy the diseased marrow or destroy the cancer elsewhere and also to suppress the patient’s own immune system (in case of allogeneic transplant), so that the blood stem cells are not rejected.

Step 2 Pre-engraftment (before the transplanted blood stem cells start working). After high dose chemo-radiotherapy, the blood stem cells are destroyed and normal blood cells are not produced. The patients need to be kept in a clean room within the BMT unit in strict isolation during this time. They also need a lot of blood and platelet transfusion.Bone Marrow Transplant Procedure

Step 3 Post-engraftment (after the transplanted blood stem cells start working). Once the donated stem cells start functioning, the patients can come out of critical isolation. As the counts of blood cells steadily increase and the patient improves clinically, he/she can be discharged. However regular checkup and follow-ups are essential to detect any health problem or graft versus host reactions.

A bone marrow transplant may completely or partially cure your illness. If the transplant is a success, you can go back to most of your normal activities as soon as you feel well enough. Most times it takes up to 1 year to recover fully.

It can take as long as a year for the new bone marrow to function normally. Patients are closely monitored during this time to identify any infections or complications that may develop.

A successful bone marrow transplant requires an expert medical team – doctors, nurses, and other support staff – who are experienced in bone marrow transplants, can promptly recognize problems and emerging side effects, and know how to react swiftly and properly if problems do arise.

A good bone marrow transplant program will also recognize the importance of providing patients and their families with emotional and psychological support before, during and after the transplant, and will make personal and other support systemsreadily available to families for this purpose. All this is and more is provided at our affiliate hospitals. We make this difficult journey easy for the patient and his relatives.

How to Get Started ?

The patient should have a related and matching donor. The following tests should be done for both patient and the related donor and also please email the reports to us for opinion by India’s leading specialist doctors

  • HLA Typing
  • Serum Ferritin Report
  • Blood Screening ReportPost a QueryPost a Query

How Can You Get a Free Expert Opinion from Top Organ Specialists in India ?

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Your case would be reviewed by best Specialists in India and an Expert Opinion with Treatment cost Estimate shall be sent to you with in 2 working days.

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