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CAR-T Cell Therapy is now available at World Class Hospitals in India at a fraction of the cost in USA & Europe.
CAR-T cell therapy – the breakthrough that got American scientist James P Allison and Japanese physician Tasuku Honjo the 2018 Nobel Prize in Medicine after more than two decades of work is now available at SafeMedTrip affiliated World Class Hospitals in India.
Successful clinical trials of CAR-T Cell Therapy on patients in India have shown excellent outcome with patients recovering totally from almost a near death stage. It has been 12 years since the first patient, Emily Whitehead (who was six then), got CAR-T cells for relapsed leukaemia at the Children’s Hospital of Philadelphia.
CAR_T Cell Therapy – Approved by Central Drugs Standard Control Organization (CDSCO) uses cutting edge genetic engineering technology to train the body’s own T Cells to fight even cancer resistant cells and offers long term survival for patients with certain types of blood cancers like lymphomas.
While conventional treatments like Chemotherapy and Radiation aim to eliminate cancer cells. CAR-T cell therapy offers a groundbreaking alternative. It harnesses the body’s own immune system by modifying T cells (immune system defenders) to specifically recognize and attack cancer cells. Equipped with Chimeric Antigen Receptors (CARs), these modified T cells act like guided missiles, precisely targeting and eliminating cancer cells.
Through a highly specialized process, T cells, a type of white blood cell crucial for fighting infections, are extracted from the patient’s blood. These are genetically modified in a lab to express a Chimeric Antigen Receptor on their surface. Once engineered, the CAR-T cells are multiplied in large numbers in a lab and then infused back into the patient’s bloodstream through an intravenous drip.
After being infused, the CAR-T cells identify and attach themselves to a specific protein on cancer cells. This triggers a robust immune response, allowing the CAR-T cells to direct cell destruction and release signals to further strengthen the anti-cancer response.
Chimeric antigen receptor (CAR) T-cell therapy works by turning T-lymphocytes (T-cells) into more efficient cancer-fighting machines. In CAR T-cell therapy, a new gene is introduced in T-cells that changes detect and kill cancerous cells. CAR T-cell therapy can cure blood cancer and also helps people with certain blood cancers live longer.
Following conditions can be successfully treated with CAR) T-cell therapy
- B-cell acute lymphoblastic Leukaemia (ALL).
- Diffuse large B-cell lymphoma.
- Follicular lymphoma.
- High-grade B-cell lymphoma.
- Mantle cell lymphoma.
- Multiple myeloma.
- Primary mediastinal large B-cell lymphoma.
For patients with relapsed or refractory CD7-positive leukaemia or lymphoma, sequential CD7 chimeric antigen receptor (CAR) T-cell therapy followed by haploidentical hematopoietic stem-cell transplantation (HSCT) is safe and effective, with remission seen for most patients.
Frequently Asked Questions about CAR T Cell Therapy
1. Is CAR T-cell a one time treatment?
Research has shown that CAR-T cells can remain in the body and continue to be active for a long period of time. So, unlike many other blood cancer drugs, CAR-T therapy is designed to be a one-time treatment.
2. How much does CAR T therapy cost?
The CAR-T therapy in the United States currently costs between $370,000 and $530,000, not including hospital fees and drugs to treat side effects. However at SafeMedTrip’s World Class network hospitals in India A single treatment of CAR T Cell NexCAR19 costs about 40,000 US Dollars only.
3. What is the recovery time after CAR-T cell Treatment ?
The acute recovery period is typically for 30 days after the CAR T-cell infusion.
4. What is the success rate of CAR T-cell therapy?
In studies, 9 out of 10 people with acute lymphoblastic leukemia whose cancer didn’t respond to other treatments or whose cancer came back had full remission with CAR T-cell therapy. Remission means the cancer can’t be detected in tests. Complete remission rates for chronic lymphocytic leukemia and non-Hodgkin lymphoma are 35–70%. Of that number, about a third have long-lasting remissions.
Some patients can be cured. For a significant number of patients, remission will be long-term.
5. Why choose World Class Hospitals in India for CAR-T cell therapy?
Our CAR-T Cell Therapy Program doctors and other specialists are highly experienced and have worked for many years at Centres of Excellence in USA and Europe. Decision for CAR T cell therapy is made after the case is discussed by a board of multidisciplinary specialists who practice evidence-based medicine. Our experts are trained to manage CAR-T cell therapy as clinical practice.
Patient Testimonial – Army Veteran Cancer Free after CAR-T cell Therapy
Dr (Col) V K Gupta has been declared cancer-free since he took the indigenously developed CAR-T cell therapy at top Cancer Hospital in India. A year ago, if someone had told Dr (Col) V K Gupta, 64, that he would not just be declared “free of cancer cells” — despite a failed bone marrow transplant in 2022 — but would be able to get back to work in 2024, he would have brushed it off as polite optimism. Months after India’s drug regulator approved the commercial use of CAR-T cell therapy, a pioneering treatment that genetically reprogrammes a patient’s immune system to fight cancer, Gupta, a Delhi based gastroenterologist, became one of the first patients to access the therapy. Doctors at the hospital, where he underwent the procedure, said he is “currently free of cancer cells”. 
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